Premi: PREMI PROFESSOR JOAQUÍN BARRAQUER
Títol del treball premiat: «Müller glia fused with adult stem cells undergo neural differentiation in human retinal models», EBioMedicine, 2022 Mar, 77
Secció: Secció Primera
Ingrés: dimarts 28 de gener de 2025, «“Cell Therapy and Reprogramming in the Eye” (vídeo Youtube: Sessió de recepció Acadèmics Corresponents Dra. Maria Pia Cosma i Dr. Juan José Sancho i Insenser )
Maria Pia Cosma es va doctorar en Genètica Cel·lular i Molecular, Facultat de Medicina, Univ. de Federico II l’any 2000. De 1997 a 2000 va ser Marie Curie postdoc a l’IMP, Viena i del 2000 al 2003 va completar la seva formació a l’Institut Teletó de Genètica i Medicina (TIGEM), Nàpols. A finals de 2003 va establir el seu primer grup a TIGEM a Nàpols i es va convertir també en Investigadora Jove (YIP) de l’EMBO. Del 2004 al 2010 ha estat professora a l’ Escola Europea de Medicina Molecular (SEMM) i investigadora associada honorària a l’IGB, CNR, Nàpols del 2009 al 2015. L’abril de 2010 es va traslladar a Barcelona, Espanya, al Centre de Regulació Genòmica (CRG) com a científica sènior i professora de recerca ICREA. Es va convertir en coordinadora del Programa de Sistemes i Biologia Sintètica del CRG des del febrer de 2023. Ha impartit nombroses xerrades a les principals conferències internacionals i instituts de recerca. Va rebre diversos premis entre els quals: Premi a l’Excel·lència Marie Curie el 2005, l’Honor de l’Ordre al Mèrit de la República Italiana el 2007, La Vanguardia de la ciencia 2014, Premi Ciutat de Barcelona el 2015, La Caixa Health 2018. Ha obtingut uan beca ERC el 2009 i HFSP el 2010. Ha estat escollida Membre de l’EMBO l’any 2010. Ha estat coordinadora del projecte FET-Open Cellviewer i del projecte associat FET-launchpad. Actualment és la coordinadora del projecte EIC Pathfinder EcaBox. Va ser escollida Campiona Nacional de l’EIC el 2021 i guardonada del Programa de Lideratge Femení de l’EIC el 2022. El grup Cosma té com a objectiu principal investigar els mecanismes de regulació del manteniment de les cèl·lules mare, la reprogramació de les cèl·lules somàtiques i la regeneració de teixits.
Publicacions seleccionades
Carnevali D, Zhong L, González-Almela E, Viana C, Rotkevich M, Wang A, Franco-Barranco, D, Gonzalez-Marfil A, Neguembor MV, Castells-Garcia A, Arganda-Carreras I and Cosma MP (2024).A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features. Nature Machine Intelligence, 6 (9):1021-1033.
Garate X, Gómez-García PA, Fernández Merino M, Cadevall Angles M, Zhu C, Castells-García A, Ed-daoui AI, Martin L, Ochiai H, Neguembor MV, Cosma MP (2024). The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition. Nucleic Acids Research June 8
Nakagawa S, Carnevali D, Xiangtian T, Alvarez MJ, Parfitt D-E, Di Vicino U, Arumugam K, Shin W, Aranda S, Normanno D, Sebastian-Perez R, Cannatá C, Cortes P, Neguembor MV, Shen MM, Califano A, Cosma MP (2024). The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development. Stem Cell Reports, Apr 26:S2213-6711(24)00110-3
Martin, L.; Neguembor, M.V.#; Cosma, M.P. # (2023). Women’s contribution in understanding how topoisomerases and supercoiling control genome organization Frontiers in Molecular Bioscience 10:1155825.
Neguembor MV, Buitrago D, Arcon JP, Lema R, Walther J, Garate X, Martin L, Romero P, AlHaj Abed J, Gut M, Blanc J, Lakadamyali M, Wu CT, Brun Heath I, Orozco M, Dans PD, and Cosma MP. (2021). MiOS, an integrated imaging and modeling strategy to resolve gene folding at basepair resolution. Nature Structure Molecular Biology, 2022 Oct;29(10):1011-1023.
Castells-Garcia A, Ed-daoui I, González-Almela E, Vicario C, Ottestrom J, Lakadamyali M, Neguembor MV, Cosma MP (2021). Super resolution microscopy reveals how elongating RNApolymerase II and nascent RNA interact with nucleosome clutches. NAR, Volume 50, Issue 1, 11 January 2022, Pages 175–190
Neguembor, MV, Castells-García A, Martin L, Vicario, C, Gómez-García, PA, AlHaj Abed, J, Granados, A, Sebastian-Perez, R, Sottile, F, Solon, Wu, CT, Lakadamyali, L, and Cosma MP (2021). Transcription controls 3D genome folding and loop extrusion. Molecular Cell, Aug 5;81(15):3065-3081.e12. Epub 2021 Jul 22. Article Cover
Gomez‐Garcia PA, Portillo‐Ledesma S, Neguembor MV, Pesaresi M, Oweis W, Rohrlich T, Wieser S, Meshorer E, Schlick T, *Cosma MP, and *Lakadamyali M. (2021) Mesoscale modeling and single nucleosome tracking reveal remodeling of clutch folding and dynamics in stem cell differentiation. Cell Reports *co-last and co-corresponding authors
Pesaresi M, Bonilla-Pons SA, Sebastian-Perez R, Di Vicino U, Alcoverro-Bertran M, Michael R and Cosma MP (2021). The chemokine receptors, Ccr5 and Cxcr6, enhance the integration of mesenchymal stem cells into the degenerating retina. Molecular Therapy.
Arumugam K, ShinW, Schiavone V, Tu T, Romo R, Paull E, Subramaniam P, WorleyJ, Califano C, CosmaMP (2020). The Master Regulator protein BAZ2B can reprogram human hematopoietic lineage-committed progenitors into a multipotent state. Cell Reports, Dec 8;33(10):108474. doi: 10.1016/j.celrep.2020.108474.
Lakadamyali, M and Cosma, M.P (2020). Visualizing the genome: high resolution imaging reveals a complex view challenging our textbook understanding. Nature Methods, 17, 371–379
Frade J, Cortes P, di Vicino U, Nakagawa S, Romo N, *LluisF and Cosma MP. (2019). Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development. Science Advances, *corresponding author
Otterstrom J, Castells Garcia A, Vicario C, *Cosma MP, *Melike Lakadamyali (2019). Super-resolution microscopy reveals nucleosomal level decompaction of chromatin upon hyperacetylation. *co-corresponding authors. NAR 2019,
Pesaresi M, Sebastian-Perez R, and Cosma MP (2019). Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine. FEBS Journal. Mar;286(6):1074-1093
Pesaresi, M, Bonilla S, Simonte G, Sanges D, Di Vicino U, and Cosma MP (2018). Endogenous mobilization of bone-marrow cells into murine retina induces fusion mediated reprogramming of Müller glia cells. eBioMedicine. 30 (2018) 38–51
Neguembor MV, Sebastian-Perez R, Aulicino F, Gomez-Garcia PA, *Cosma MP, and *Lakadamyali M (2018). PoSTAC (Polycistronic SunTAg modified CRISPR) enables live-cell and super resolution visualization of multiple genes. Nucleic Acids Res. Mar 16;46(5):e30.*co-corresponding authors.
Pedone E, Oltenau VA, Marucci L, Muñoz-Martin MI, Youssef SA, de Bruin A, and Cosma MP (2017). Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration. Cell Reports, 18, 107–121
De Jaime-Soguero A, Aulicino F, Ertaylan G, Grieco A, Cerrato A, Tallam A, del Sol A, *Cosma MP and *Lluis F and (2017). Wnt/b-catenin/Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4/Arf locus. Plos Genetics, *co-last authors
Sanges D, Simonte G DiVicino U, Romo N, Pinilla I, Nicolás Farrés M and Cosma MP (2016). In vivo conversion of Müller glia into photoreceptors through cell fusion-mediated reprogramming. Journal of Clinical Investigation, Aug 1;126(8):3104-16.
Altarche-Xifro W, di Vicino U, Muñoz-Martin MI, Bové J, Vila M and CosmaMP (2016). Functional rescue of dopaminergic neuron loss in Parkinson’s disease mice after transplantation of hematopoietic stem and progenitor cells, eBioMedicine, Jun;8:83-95
Ricci MA, Manzo C, García-Parajo M, *Lakadamyali M, and *Cosma MP (2015). Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo. Cell, *co-last authors. Nominated F1000Prime 2015 https://www.youtube.com/watch?v=5KSr-giy8qo
Marucci L, Pedone E, Di Vicino U, Sanuy-Escribano B, Isalan M, and Cosma MP. Beta-Catenin fluctuates in mouse ESCs and Is essential for Nanog-mediated reprogramming of somatic cells to pluripotency. Cell Reports, Sep 25;8(6):1686-96 (2014).
Aulicino F, Theka I, Ombrato L, Lluis F, Cosma MP (2014) Temporal perturbation of the Wnt signalling pathway controls cell reprogramming via Tcf1 activity. Stem Cell Reports, May 8;2(5):707-20.
Sanges D, Romo N, Simonte G, Di Vicino U, Tahoces AD, Fernández E, Cosma MP. (2013) Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina. Cell Reports Jul 25;4(2):271-86.
Lluis F, Ombrato L, Pedone E, Pepe S, Merrill BJ, Cosma MP. (2011) T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications. PNAS Jul 19;108(29):11912-7.
Lluis F, Pedone E, Pepe S, Cosma MP. The Wnt/β-Catenin Signaling Pathway Tips the Balance Apoptosis and Reprogramming of Cell-Fusion Hybrids. Stem Cells. 2010 Sep 8. 2010 Nov;28(11):1940-9
Cantone I, Marucci L, Iorio F, Ricci MA, Belcastro V, Bansal M, di Bernardo M, Santini D, *di Bernardo D and *Cosma MP (2009). A yeast synthetic network for In-vivo assessment of reverse-engineering and modelling approaches. Cell Apr 3;137(1):172-81. *co-last authors.
Lluis F, Pedone E, Pepe S, Cosma MP (2008). Periodic activation of Wnt/beta-catenin signalling enhances somatic cell reprogramming mediated by cell fusion. Cell Stem Cell. Nov 6;3(5):493-507